Trifluoroacetic acid → HCID 54591107、化合物
反応式
COC1C=CC(C[N:8]2[N:14]=[C:13]([N:15]3[CH2:20][CH2:19][C:18]4[N:21]=[C:22]([C:24]5[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=5)[O:23][C:17]=4[CH2:16]3)[CH:12]3[CH:10]([CH2:11]3)[C:9]2=[O:30])=CC=1.C1(OC)C(=CC=CC=1)OC.C(O)(C(F)(F)F)=O.C(=O)([O-])[O-].[Na+].[Na+]>>[C:24]1([C:22]2[O:23][C:17]3[CH2:16][N:15]([C:13]4[CH:12]5[CH:10]([CH2:11]5)[C:9](=[O:30])[NH:8][N:14]=4)[CH2:20][CH2:19][C:18]=3[N:21]=2)[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1参加物
5
実験手順
320 mg (0.75 mmol) 3-(4-methoxy-benzyl)-5-(2-phenyl-6,7-dihydro-4H-oxazolo[5,4-c]pyridin-5-yl)-3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one, 1 ml (7.84 mmol) Veratrol and 6 ml TFA are heated to 100° C. in a pressure vessel for 24 h. The cooled mixture is combined with sat. sodium carbonate solution and extracted with DCM, the org. phase is concentrated by rotary evaporation i. V. and the residue is purified by silica gel (eluant: DCM/methanol).