Ethanol → HCID 67288578、化合物

HRID 1626478ノート

反応式

HRID 1626478 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19](=[O:31])[NH:20][CH2:21][CH2:22][C:23]3[C:28]([Cl:29])=[CH:27][C:26]([Cl:30])=[CH:25][N:24]=3)=[CH:15][CH:14]=1)[O:8][CH2:7][CH2:6][CH:5]2[C:32]([O:34]CC)=[O:33].[OH-].[Na+].[CH2:39](O)[CH3:40]>C1COCC1.C(OCC)(=O)C.Cl>[CH2:39]([CH:7]1[CH2:6][CH:5]([C:32]([OH:34])=[O:33])[C:4]2[C:9](=[CH:10][C:11]([O:12][C:13]3[CH:18]=[CH:17][C:16]([C:19](=[O:31])[NH:20][CH2:21][CH2:22][C:23]4[C:28]([Cl:29])=[CH:27][C:26]([Cl:30])=[CH:25][N:24]=4)=[CH:15][CH:14]=3)=[C:2]([Cl:1])[CH:3]=2)[O:8]1)[CH3:40]

参加物

7

反応物 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 67288212HCID 67288212、化合物

生成物 1

HCID 67288578HCID 67288578、化合物収率 100%

試薬・触媒・溶媒 3

HCID 313Hydrochloric Acid溶媒HCID 8028Tetrahydrofuran溶媒HCID 8857Ethyl Acetate溶媒

実験手順

Ethyl 6-chloro-7-(4-(2-(3,5-dichloropyridin-2-yl)ethylcarbamoyl)phenoxy)chroman-4-carboxylate (40 mg, 0.073 mmol) was diluted with THF (500 μl) followed by the addition of NaOH (364 μl, 0.36 mmol) and ethanol (300 μl). After stirring for 3 hours, the reaction was diluted with ethyl acetate and 2N HCl. The layers were separated and the organic layer was dried over MgSO4, filtered and concentrated to yield the desired compound (38 mg, 0.073 mmol, 100% yield).

後処理

  1. customThe layers were separated
  2. dry with materialthe organic layer was dried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-e6710fa5722e4f58a97478b98e4c6ec6
出典データセット
uspto-grants-2014_07
特許番号
US08785445B2

反応ノート

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