HCID 68736178、化合物 → 4-Methyl-6-pyrrolidin-1-ylpyridin-3-amine
反応式
[CH3:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][N:5]=[C:4]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)[CH:3]=1>[Pd].O1CCCC1>[CH3:1][C:2]1[CH:3]=[C:4]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)[N:5]=[CH:6][C:7]=1[NH2:8]参加物
4
実験手順
A mixture of 4-methyl-5-nitro-2-pyrrolidin-1-ylpyridine (2.08 g, 10.0 mmol) and 10% palladium on carbon (208 mg) in tetrahydrofuran (10 mL) was stirred under hydrogen atmosphere at room temperature for 16 hr. Catalyst was removed by filtration and the filtrate was concentrated in vacuo to give the title compound (1.76 g, 9.89 mmol, 99%) as a purple solid.
後処理
- customCatalyst was removed by filtration
- concentrationthe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-aaba259f9c8e45c58d8abbfff5aed927
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08785460B2
反応ノート
読み込み中…