Methyl 4-[(2,6-dinitrophenyl)amino]-3-hydroxybutanoate → Methyl 4-[(2,6-diaminophenyl)amino]-3-hydroxybutanoate

HRID 1628448ノート

反応式

HRID 1628448 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-])=O)[C:5]=1[NH:13][CH2:14][CH:15]([OH:21])[CH2:16][C:17]([O:19][CH3:20])=[O:18])([O-])=O>[Pd].O1CCCC1>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([NH2:10])[C:5]=1[NH:13][CH2:14][CH:15]([OH:21])[CH2:16][C:17]([O:19][CH3:20])=[O:18]

参加物

4

反応物 1

HCID 86632868Methyl 4-[(2,6-dinitrophenyl)amino]-3-hydroxybutanoate

生成物 1

HCID 68737495Methyl 4-[(2,6-diaminophenyl)amino]-3-hydroxybutanoate収率 99%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

Under hydrogen gas atmosphere, a mixture of methyl 4-[(2,6-dinitrophenyl)amino]-3-hydroxybutanoate (Reference Example 79; 2.53 g, 8.45 mmol), 10% palladium on carbon (50% wet, 500 mg) and tetrahydrofuran (85 mL) was stirred at room temperature for 6 hr. The reaction mixture was filtered and concentrated in vacuo to give the title compound as a solid (2.00 g, 8.36 mmol, 99%).

後処理

  1. filtrationThe reaction mixture was filtered
  2. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-fc8257e62e5f472cad901fece4160824
出典データセット
uspto-grants-2014_07
特許番号
US08785460B2

反応ノート

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