Aniline → 2H-Benzimidazol-2-one, 1,3-dihydro-1-phenyl-

HRID 1634023

反応式

HRID 1634023 の反応式
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-])=O.[NH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[C:18]([O-])([O-])=[O:19].[K+].[K+]>CC#N>[C:3]1([N:8]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[NH:11][C:18]2=[O:19])[CH:4]=[CH:5][CH:6]=[CH:7][CH:2]=1

参加物

5

反応物 3

HCID 6115AnilineHCID 11430Potassium CarbonateHCID 738951-Fluoro-2-nitrobenzene

生成物 1

HCID 846572H-Benzimidazol-2-one, 1,3-dihydro-1-phenyl-

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

2-fluoronitrobenzene was treated with aniline in the prescence of K2CO3 in CH3CN and heated to reflux for 12 h. The solution is cooled, filtered and the solvent removed. The nitro group is reduced with catalytic hydrogenation and the diamine treated with CDI to give 1-phenyl-1,3-dihydro-benzoimidazol-2-one.

後処理

  1. temperatureheated
  2. temperatureto reflux for 12 h
  3. temperatureThe solution is cooled
  4. filtrationfiltered
  5. customthe solvent removed
  6. additionthe diamine treated with CDI

出典と根拠

ORDレコード
ord-6ce79da2204742599c88902fe82d6331
出典データセット
uspto-grants-2003_01
特許番号
US06506738B1

関連ノート

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