Hydrogen Bromide → Ethyl 2-bromo-3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]propanoate

HRID 1634520

反応式

HRID 1634520 の反応式
N[C:2]1[CH:3]=[CH:4][C:5]([O:22][CH3:23])=[C:6]([CH:21]=1)[C:7]([NH:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=1)=[O:8].[BrH:24].N([O-])=O.[Na+].[C:29]([O:33][CH2:34][CH3:35])(=[O:32])[CH:30]=[CH2:31].C(=O)([O-])O.[Na+]>[Cu]=O.O.CO.CC(C)=O>[Br:24][CH:30]([CH2:31][C:2]1[CH:3]=[CH:4][C:5]([O:22][CH3:23])=[C:6]([C:7](=[O:8])[NH:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)[CH:21]=1)[C:29]([O:33][CH2:34][CH3:35])=[O:32]

参加物

10

反応物 5

HCID 260Hydrogen BromideHCID 8821Ethyl AcrylateHCID 516892Sodium BicarbonateHCID 109034245-amino-2-methoxy-N-(4-trifluoromethylbenzyl)benzamideHCID 23668193Sodium Nitrite

生成物 1

HCID 10874612Ethyl 2-bromo-3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]propanoate収率 71%

試薬・触媒・溶媒 4

HCID 14829Copper oxide触媒HCID 180Acetone溶媒HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

5-Amino-2-methoxy-N-[[4-(trifluoromethyl)phenyl]-methyl]benzamide (7.00 g, 21.6 mmol), 85 ml of acetone and 34 ml of methanol were mixed, which was cooled with ice. Under stirring, 17.5 ml of 47% hydrobromic acid, sodium nitrite (1.65 g, 23.9 mmol) and 6.2 ml of water were added and the mixture was stirred for 10 minutes. Next, ethyl acrylate (13.4 ml, 128 mmol) and copper oxide (I) (416 mg, 2.91 mmol) were added at room temperature. After stirring for 30 minutes, the reaction mixture was poured into saturated aqueous solution of sodium hydrogencarbonate, which was extracted with ethyl acetate. The extract was washed with brine, then dried over anhydrous magnesium sulfate and concentrated. The residue was recrystallized from a mixed solvent of n-hexane with ethyl acetate to obtain 683 mg (71%) of the title compound as colorless crystals.

後処理

  1. temperaturewhich was cooled with ice
  2. stirringthe mixture was stirred for 10 minutes
  3. stirringAfter stirring for 30 minutes
  4. extractionwas extracted with ethyl acetate
  5. washThe extract was washed with brine
  6. dry with materialdried over anhydrous magnesium sulfate
  7. concentrationconcentrated
  8. customThe residue was recrystallized from a mixed solvent of n-hexane with ethyl acetate

出典と根拠

ORDレコード
ord-4d2ac8cc696048c19d61838b81f597a0
出典データセット
uspto-grants-2003_01
特許番号
US06506797B1

関連ノート

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