Acetic Acid → Phenol, 2-fluoro-, acetate

HRID 1634731ノート

反応式

HRID 1634731 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].[C:9](O)(=[O:11])[CH3:10]>S(Cl)(Cl)=O>[C:9]([O:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[F:1])(=[O:11])[CH3:10]

参加物

4

反応物 2

HCID 176Acetic AcidHCID 97072-Fluorophenol

生成物 1

HCID 141495Phenol, 2-fluoro-, acetate

試薬・触媒・溶媒 1

HCID 24386Thionyl Chloride溶媒

反応条件

温度
150 °C

実験手順

2-Fluorophenol (99.4 g, 886.7 mmol) was stirred in thionyl chloride (71.2 mL) and acetic acid (51 mL) added. After the initial reaction had subsided the mixture was heated to reflux for 4 hours. The solution was then heated at 150° C. overnight. The resulting dark solution was distilled under reduced pressure at an oil bath temperature of 190° C. to give the title compound as a pale yellow oil (120.9 g, 784.4 mmol).

後処理

  1. customAfter the initial reaction
  2. temperaturewas heated
  3. temperatureto reflux for 4 hours
  4. distillationThe resulting dark solution was distilled under reduced pressure at an oil bath temperature of 190° C.

出典と根拠

ORDレコード
ord-b567c8675b3744318ba9586de73a7f70
出典データセット
uspto-grants-2003_01
特許番号
US06506901B2

反応ノート

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