Ammonium formate → HCID 70001232、化合物

HRID 1634795ノート

反応式

HRID 1634795 の反応式
C([O:3][C:4](=[O:41])[C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([N:14]2[CH2:19][CH2:18][CH:17]([CH2:20][NH:21][CH2:22][C@H:23]([OH:40])[CH2:24][O:25][C:26]3[CH:31]=[CH:30][C:29]([O:32][CH2:33][C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)=[CH:28][CH:27]=3)[CH2:16][CH2:15]2)=[O:13])=[CH:7][CH:6]=1)C.C([O-])=O.[NH4+]>CO.[Pd]>[OH:40][C@H:23]([CH2:24][O:25][C:26]1[CH:31]=[CH:30][C:29]([O:32][CH2:33][C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=2)=[CH:28][CH:27]=1)[CH2:22][NH:21][CH2:20][CH:17]1[CH2:16][CH2:15][N:14]([C:12]([NH:11][C:8]2[CH:9]=[CH:10][C:5]([C:4]([OH:41])=[O:3])=[CH:6][CH:7]=2)=[O:13])[CH2:19][CH2:18]1

参加物

5

反応物 2

HCID 2723923Ammonium formateHCID 69999017HCID 69999017、化合物

生成物 1

HCID 70001232HCID 70001232、化合物収率 26.6%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 4-[(4-{[(2S)-2-hydroxy-3-(4-benzyloxy-phenoxy)-propylamino]-methyl}-piperidine-1-carbonyl)-amino]-benzoic acid ethyl ester (0.11 g, 0.43 mmol) and ammonium formate (0.063 g, 1 mmol) in 5 mL of methanol over 0.110 g of 10% palladium on carbon was stirred at ambient temperature overnight. The catalyst was filtered (solka floc) and the filtrate concentrated in vacuo. Trituration of the crude solid foam with Et2O provided 0.061 g of the title compound as a white solid.

後処理

  1. filtrationThe catalyst was filtered (solka floc)
  2. concentrationthe filtrate concentrated in vacuo

出典と根拠

ORDレコード
ord-d3a51b463ce64ed181a51d0847bfb172
出典データセット
uspto-grants-2003_01
特許番号
US06506901B2

反応ノート

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