Thionyl Chloride → 2-(3,4,5-Trimethoxyphenyl)benzyl chloride
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=2[CH2:15]O)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].S(Cl)([Cl:23])=O>C(Cl)(Cl)Cl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=2[CH2:15][Cl:23])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10]参加物
4
実験手順
2-(3,4,5-Trimethoxyphenyl)benzyl alcohol (630 mg) was dissolved in chloroform (10 mL), and to the solution thionyl chloride (0.153 mL) was added at 0° C. After 30 minutes, the mixture was warmed to room temperature and stirred for 4 hours. The reaction mixture was washed with water and saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was then recrystallized from chloroform-hexane to obtain the title compound.