4-Methylmorpholine → N,N-di-n-Butyl-2-benzyloxyacetamide

HRID 1635076

反応式

HRID 1635076 の反応式
CN1CCOCC1.ClC(OCC(C)C)=O.[CH2:16]([O:23][CH2:24][C:25]([OH:27])=O)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[CH2:28]([NH:32][CH2:33][CH2:34][CH2:35][CH3:36])[CH2:29][CH2:30][CH3:31]>C1COCC1.O>[CH2:28]([N:32]([CH2:33][CH2:34][CH2:35][CH3:36])[C:25](=[O:27])[CH2:24][O:23][CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)[CH2:29][CH2:30][CH3:31]

参加物

7

反応物 4

HCID 79724-Methylmorpholine2 回HCID 8148DibutylamineHCID 62365Isobutyl chloroformateHCID 290301(Benzyloxy)acetic acid

生成物 1

HCID 18675619N,N-di-n-Butyl-2-benzyloxyacetamide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

3 g of N-methylmorpholine and 4 g of isobutyl chloroformate were successively added dropwise to 5 g of 2-benzyloxyacetic acid in 50 ml of THF at −10° C. The mixture was stirred for 10 minutes and then 5 ml of di-n-butylamine and a further 3 g of N-methylmorpholine were added. After one hour, the mixture was added to 500 ml of water and extracted several times with ether. The collected organic phases were dried over magnesium sulfate and, after removal of the solvent by distillation, 7 g of an oil were isolated and were immediately employed further.

後処理

  1. waitAfter one hour
  2. extractionextracted several times with ether
  3. dry with materialThe collected organic phases were dried over magnesium sulfate
  4. customafter removal of the solvent
  5. distillationby distillation

出典と根拠

ORDレコード
ord-72439baae5ef4e1f8fdc8da1bc0db42f
出典データセット
uspto-grants-2003_01
特許番号
US06509341B1

関連ノート

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