Acetic Acid → 8-(3-Aminopiperidinyl)-1-Ethyl-9-Methoxy-4-Oxo-4H-Quinolizine-3-Carboxylic Acid

HRID 1635096ノート

反応式

HRID 1635096 の反応式
[NH2:1][CH:2]1[CH2:7][CH2:6][CH2:5][N:4]([C:8]2[CH:9]=[CH:10][N:11]3[C:16]([C:17]=2[O:18][CH3:19])=[C:15]([CH2:20][CH3:21])[CH:14]=[C:13]([C:22]([O:24]CC)=[O:23])[C:12]3=[O:27])[CH2:3]1.[OH-].[Li+].C(O)(=O)C>O.C1COCC1>[NH2:1][CH:2]1[CH2:7][CH2:6][CH2:5][N:4]([C:8]2[CH:9]=[CH:10][N:11]3[C:16]([C:17]=2[O:18][CH3:19])=[C:15]([CH2:20][CH3:21])[CH:14]=[C:13]([C:22]([OH:24])=[O:23])[C:12]3=[O:27])[CH2:3]1

参加物

6

反応物 3

HCID 176Acetic AcidHCID 3939Lithium HydroxideHCID 865895428-(3-Aminopiperidinyl)-1-Ethyl-9-Methoxy-4-Oxo-4H-Quinolizine-3-Carboxylic Acid, Ethyl Ester

生成物 1

HCID 186758698-(3-Aminopiperidinyl)-1-Ethyl-9-Methoxy-4-Oxo-4H-Quinolizine-3-Carboxylic Acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
60 °C

実験手順

8-(3-aminopiperidinyl)-1-ethyl-9-methoxy-4-oxo-4H-quinolizine-3-carboxylic acid, ethyl ester (0.028 g) is dissolved in 9 ml of a 2/1 mixture of water and THF and lithium hydroxide (0.035 g) is added. The resulting solution is stirred at 60° C. for 4 days and the solution adjusted to pH 7.2 by addition of acetic acid. The title compound is collected by filtration of the precipitate.

後処理

  1. additionis added
  2. filtrationThe title compound is collected by filtration of the precipitate

出典と根拠

ORDレコード
ord-60347c174eb545f8afd1c725a5fbb70e
出典データセット
uspto-grants-2003_01
特許番号
US06509349B1

反応ノート

読み込み中…