Isoamylamine → HCID 18676169、化合物

HRID 1635577ノート

反応式

HRID 1635577 の反応式
[CH3:1][C:2]1[N:3]=[C:4]([CH:8]=O)[NH:5][C:6]=1[CH3:7].[CH2:10]([NH2:15])[CH2:11][CH:12]([CH3:14])[CH3:13]>[Pt](=O)=O.C(O)C>[CH3:1][C:2]1[N:3]=[C:4]([CH2:8][NH:15][CH2:10][CH2:11][CH:12]([CH3:14])[CH3:13])[NH:5][C:6]=1[CH3:7]

参加物

5

反応物 2

HCID 7894IsoamylamineHCID 126571174,5-Dimethyl-1H-imidazole-2-carbaldehyde

生成物 1

HCID 18676169HCID 18676169、化合物収率 98%

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 702Ethanol溶媒

実験手順

A mixture of 3.35 g (27 mmol) of 4,5-dimethyl-2-imidazolecarboxaldehyde, 9.0 mL (77 mmol) of isoamylamine, 200 mL of ethanol, and 0.20 g of platinum dioxide is hydrogenated under 50 psi of pressure at 22° C. for 24 h. The solution is filtered, and the volatiles are evaporated under reduced pressure to give 5.17 g (98%) of N-[(4,5-dimethylimidazol-2-yl)methyl]-(3-methylbutyl)amine. Mass Spec m/z (M++1) 196.

後処理

  1. filtrationThe solution is filtered
  2. customthe volatiles are evaporated under reduced pressure

出典と根拠

ORDレコード
ord-110f4c22d9b547098fdc4422270fc156
出典データセット
uspto-grants-2003_01
特許番号
US06509366B2

反応ノート

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