Nitric Acid → 2-Iodo-5-nitrobenzoic acid

HRID 1635800

反応式

HRID 1635800 の反応式
[I:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[N+:11]([O-])([OH:13])=[O:12]>S(=O)(=O)(O)O>[I:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 69412-Iodobenzoic acid

生成物 1

HCID 38487452-Iodo-5-nitrobenzoic acid

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

反応条件

温度
80 °C

実験手順

2-Iodobenzoic acid (100 g) was dissolved in 400 mL of concentrated sulphuric acid and placed in a 2 liter 3 necked flask. The flask was fitted with reflux condenser, a thermometer and an addition funnel. Fuming nitric acid (400 ml) was added drop by drop. The addition was adjusted in such a way that the temperature was allowed to raise to 80° C. over a period of 2 hours. During the addition, the reaction mixture was stirred vigorously and maintained the temperature at 80° C. for an additional 2 hours. After the completion of the reaction, the reaction mixture was poured slowly into crushed ice (3 Kg). The contents were allowed to settle and were filtered. The yellow precipitate was collected and dried at 30° C. The yield was 90 grams.

後処理

  1. customThe flask was fitted
  2. temperaturewith reflux condenser
  3. additionThe addition
  4. additionDuring the addition
  5. temperaturemaintained the temperature at 80° C. for an additional 2 hours
  6. customAfter the completion of the reaction
  7. additionthe reaction mixture was poured slowly
  8. filtrationwere filtered
  9. customThe yellow precipitate was collected
  10. customdried at 30° C

出典と根拠

ORDレコード
ord-5413640b64a34d15ad4c3bf5f450b55e
出典データセット
uspto-grants-2003_01
特許番号
US06511988B2

関連ノート

読み込み中…