Dimethoxymethane → 4-(Ethylthio)benzyl chloride

HRID 1635964

反応式

HRID 1635964 の反応式
[Cl-:1].[Al+3].[Cl-].[Cl-].[CH3:5]OCOC.[CH2:10]([S:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH3:11]>ClCCCl>[CH2:10]([S:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:5][Cl:1])=[CH:15][CH:14]=1)[CH3:11]

参加物

5

反応物 3

HCID 8020DimethoxymethaneHCID 12144(Ethylthio)benzeneHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 186738584-(Ethylthio)benzyl chloride

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

反応条件

温度
5 °C

実験手順

Aluminum chloride (2 g, 15 mmol) was suspended in 8 mL 1,2-dichloroethane and the solution was cooled to 5° C. Dimethoxymethane (0.69 mL, 7.8 mmol) over 10 min. Ethylphenylsulfide (0.88 mL, 6.5 mmol) was added and the mixture was warmed to rt. After 15 h ice water was added and the mixture was extracted with methylene chloride (3×). The combined organic fractions were dried over magnesium sulfate and concentrated. The crude material was used directly in the next step.

後処理

  1. temperaturethe mixture was warmed to rt
  2. extractionthe mixture was extracted with methylene chloride (3×)
  3. dry with materialThe combined organic fractions were dried over magnesium sulfate
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-28964c644ded4d8ebef150e94210722b
出典データセット
uspto-grants-2003_01
特許番号
US06511994B2

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