Iodine chloride → 2-(4'-Amino-3'-iodophenyl)-6-methoxybenzothiazole

HRID 1636554

反応式

HRID 1636554 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]3[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1.[I:19]Cl>C(O)(=O)C>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:9][C:10]3[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:6][C:7]=1[I:19]

参加物

4

反応物 2

HCID 24640Iodine chlorideHCID 3918704-(6-Methoxy-1,3-benzothiazol-2-yl)aniline

生成物 1

HCID 100684372-(4'-Amino-3'-iodophenyl)-6-methoxybenzothiazole収率 56.1%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

2-(4'-Aminophenyl)-6-methoxybenzothiazole (0.22 g, 0.84 mmol) was treated with iodine monochloride (0.21 g, 1.3 mmol) in acetic acid according to the above-described general procedure for iodination. Crude product was purified by flash chromatography on silica gel, using ethyl acetate-hexane (1:3) as eluent, to give brown small crystals (0.18 g, 54.9%), m.p. 179.2-181.1° C.

後処理

  1. customCrude product was purified by flash chromatography on silica gel

出典と根拠

ORDレコード
ord-06fc31bab1024d1a891d176b03be7e52
出典データセット
uspto-grants-2000_03
特許番号
US06034246

関連ノート

読み込み中…