Trityl chloride → Ethyl 1-trityl-1H-imidazole-4-carboxylate

HRID 1636813ノート

反応式

HRID 1636813 の反応式
[NH:1]1[CH:5]=[C:4]([C:6]([O:8][CH2:9][CH3:10])=[O:7])[N:3]=[CH:2]1.C(N(CC)CC)C.[C:18](Cl)([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(Cl)(Cl)Cl>[C:18]([N:1]1[CH:5]=[C:4]([C:6]([O:8][CH2:9][CH3:10])=[O:7])[N:3]=[CH:2]1)([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

参加物

5

反応物 3

HCID 6456Trityl chlorideHCID 8471TriethylamineHCID 178469898HCID 178469898、化合物

生成物 1

HCID 618225Ethyl 1-trityl-1H-imidazole-4-carboxylate

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A suspension of ethyl imidazole-4-carboxylate (1.4 g), triethylamine (1.2 g) and chloroform (20 ml) was stirred at room temperature while trityl chloride (3.06 g) was added, and the mixture was stirred at room temperature for 1 h. The resulting solution was washed with water, dried and evaporated to dryness under reduced pressure, and the residue was crystallised from a mixture of ethyl acetate and cyclohexane, to give ethyl 1-tritylimidazole-4-carboxylate, mp 163°-164°.

後処理

  1. additionwas added
  2. washThe resulting solution was washed with water
  3. customdried
  4. customevaporated to dryness under reduced pressure
  5. customthe residue was crystallised from a mixture of ethyl acetate and cyclohexane

出典と根拠

ORDレコード
ord-91ce51a165e840c2a0015a804d1ff624
出典データセット
uspto-grants-2000_03
特許番号
USRE036617

反応ノート

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