Water → 4-allyloxy-3-methyl-5,6,7,8-tetrahydroquinoline-N-oxide

HRID 1638577ノート

反応式

HRID 1638577 の反応式
[CH3:1][C:2]1[CH:3]=[N+:4]([O-:15])[C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:10]=2[C:11]=1[N+]([O-])=O.[OH-].[Na+].O.[CH2:19]([OH:22])[CH:20]=[CH2:21]>>[CH2:19]([O:22][C:11]1[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[N+:4]([O-:15])=[CH:3][C:2]=1[CH3:1])[CH:20]=[CH2:21]

参加物

5

反応物 4

HCID 962WaterHCID 7858Allyl AlcoholHCID 14798Sodium HydroxideHCID 139602613-methyl-4-nitro-5,6,7,8-tetrahydroquinoline-N-oxide

生成物 1

HCID 141555204-allyloxy-3-methyl-5,6,7,8-tetrahydroquinoline-N-oxide

実験手順

2.0 Grams of 3-methyl-4-nitro-5,6,7,8tetrahydroquinoline-N-oxide was dissolved in allyl alcohol. Then 0.6 g of sodium hydroxide was added thereto, and the mixture was stirred at 70°-80° C. for 3 hours. After the reaction was completed, the reaction mixture was concentrated under reduced pressure, to the residue thus obtained was added water, and was extracted with chloroform. The chloroform layer was washed with an aqueous solution saturated with sodium chloride, then dried with anhydrous magnsium sulfate. Chloroform was removed by evaporation under reduced pressure to obtain 1.4 g of 4-allyloxy-3-methyl-5,6,7,8-tetrahydroquinoline-N-oxide in the form of brown oily substance.

後処理

  1. concentrationthe reaction mixture was concentrated under reduced pressure, to the residue
  2. customthus obtained
  3. extractionwas extracted with chloroform
  4. washThe chloroform layer was washed with an aqueous solution saturated with sodium chloride
  5. dry with materialdried with anhydrous magnsium sulfate
  6. customChloroform was removed by evaporation under reduced pressure

出典と根拠

ORDレコード
ord-22176e2832704fe880ec6c6d19284215
出典データセット
uspto-grants-1989_11
特許番号
US04880815

反応ノート

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