Sodium Hydroxide → HCID 19833129、化合物

HRID 1639375ノート

反応式

HRID 1639375 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[Cl:7][C:8]1[C:22]([Cl:23])=[CH:21][C:11]2[C:12]3[CH2:13][CH2:14][C:15](=O)[NH:16][C:17]=3[CH2:18][CH2:19][C:10]=2[CH:9]=1.[OH-].[Na+]>O1CCCC1>[Cl:7][C:8]1[C:22]([Cl:23])=[CH:21][C:11]2[C:12]3[CH2:13][CH2:14][CH2:15][NH:16][C:17]=3[CH2:18][CH2:19][C:10]=2[CH:9]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 19791550HCID 19791550、化合物HCID 21226445Aluminium lithium hydride

生成物 1

HCID 19833129HCID 19833129、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

1.57 g (0.042 mol) of lithium aluminum hydride are suspended in 60 ml of tetrahydrofuran under argon, 5.56 g (0.021 mol) of 8,9-dichloro-1,4,5,6-tetrahydrobenzo[f]-quinolin-3(2H)-one are slowly added thereto and the mixture is boiled under reflux for 2.5 hours. The mixture is then cooled to 0°, 5.2 ml of 18 percent sodium hydroxide solution are added dropwise thereto and the precipitate formed is removed by filtration. On evaporation of the filtrate, there is obtained 8,9-dichloro-1,2,3,4,5,6-hexahydrobenzo[f]quinoline as a yellow oil which is processed directly.

後処理

  1. temperatureunder reflux for 2.5 hours
  2. temperatureThe mixture is then cooled to 0°
  3. customthe precipitate formed
  4. customis removed by filtration
  5. customOn evaporation of the filtrate

出典と根拠

ORDレコード
ord-4a52199af18f4df4b8114616b334c3bc
出典データセット
uspto-grants-1989_11
特許番号
US04883815

反応ノート

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