Sodium Hydroxide → trans-2-(2-methyl-2H-indazol-4-yl)cyclopropanecarbaldehyde oxime

HRID 1639755ノート

反応式

HRID 1639755 の反応式
[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([CH:5]=[CH:6][CH:7]=[C:8]2[C@@H:11]2[CH2:13][C@H:12]2[CH:14]=O)=[N:3]1.[OH-:16].[Na+].Cl.[NH2:19]O>C(O)C.O>[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([CH:5]=[CH:6][CH:7]=[C:8]2[C@@H:11]2[CH2:13][C@H:12]2[CH:14]=[N:19][OH:16])=[N:3]1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 86641920trans-2-(2-methyl-2H-indazol-4-yl)cyclopropanecarbaldehyde

生成物 1

HCID 86641922trans-2-(2-methyl-2H-indazol-4-yl)cyclopropanecarbaldehyde oxime収率 98.3%

試薬・触媒・溶媒 1

HCID 19096565Water ethanol溶媒

反応条件

温度
60 °C

実験手順

Trans-2-(2-methyl-2H-indazol-4-yl)cyclopropanecarbaldehyde (330 mg, 1.65 mmol), 8 M aqueous sodium hydroxide solution (824 μL, 6.59 mmol) and hydroxylamine hydrochloride (378 mg, 5.44 mmol) were dissolved in ethanol/water (15 mL/3 mL), and the mixture was stirred at 60° C. for 3 hr. The reaction solution was concentrated, extracted with ethyl acetate, washed with saturated brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (349 mg, yield 98%).

後処理

  1. concentrationThe reaction solution was concentrated
  2. extractionextracted with ethyl acetate
  3. washwashed with saturated brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-967d83feb3834e60b42f321216201b05
出典データセット
uspto-grants-2012_02
特許番号
US08110585B2

反応ノート

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