Sodium Hydroxide → 2,3-dihydro-1H-indol-5-ol

HRID 1640256ノート

反応式

HRID 1640256 の反応式
C([BH3-])#N.[Na+].[OH:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][CH:10]=[CH:9]2.[OH-].[Na+]>C(O)(=O)C>[NH:11]1[C:12]2[C:8](=[CH:7][C:6]([OH:5])=[CH:14][CH:13]=2)[CH2:9][CH2:10]1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 160545-HydroxyindoleHCID 5003444Sodium cyanoborohydride

生成物 1

HCID 100346842,3-dihydro-1H-indol-5-ol

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Under a nitrogen atmosphere 0.34 g sodium cyanoborohydride were added batchwise to 0.60 g (4.5 mmol) 5-hydroxyindole in 5.0 mL glacial acetic acid and the mixture was stirred for 60 min at RT. Then the reaction mixture was poured onto a 4N aqueous sodium hydroxide solution and extracted with EtOAc. The combined organic phases were washed several times with saturated sodium hydrogen carbonate solution, dried on sodium sulphate and evaporated down.

後処理

  1. extractionextracted with EtOAc
  2. washThe combined organic phases were washed several times with saturated sodium hydrogen carbonate solution
  3. customdried on sodium sulphate
  4. customevaporated down

出典と根拠

ORDレコード
ord-7fb701233e8b4271a07233300e72cd16
出典データセット
uspto-grants-2012_02
特許番号
US08110575B2

反応ノート

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