4-(2-Fluoro-4-nitrophenoxy)-1-benzofuran → 4-(1-Benzofuran-4-yloxy)-3-fluorophenylamine

HRID 16410

反応式

HRID 16410 の反応式
[F:1][C:2]1[CH:17]=[C:16]([N+:18]([O-])=O)[CH:15]=[CH:14][C:3]=1[O:4][C:5]1[C:10]2[CH:11]=[CH:12][O:13][C:9]=2[CH:8]=[CH:7][CH:6]=1>C(O)C.O1CCCC1.[Pt](=O)=O>[O:13]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([O:4][C:3]3[CH:14]=[CH:15][C:16]([NH2:18])=[CH:17][C:2]=3[F:1])[C:10]=2[CH:11]=[CH:12]1

参加物

4

反応物 1

HCID 179793424-(2-Fluoro-4-nitrophenoxy)-1-benzofuran

生成物 1

HCID 179793044-(1-Benzofuran-4-yloxy)-3-fluorophenylamine

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 21873804Tetrahydrofuran ethanol溶媒

実験手順

Under argon, 150 mg (0.55 mmol) of 4-(2-fluoro-4-nitrophenoxy)-1-benzofuran (from example XXII) are initially charged in 5 ml of ethanol/tetrahydrofuran (1:1), platinum(IV) oxide is added and the mixture is hydrogenated under atmospheric pressure for 2 hours. The suspension is filtered off through CELITE (diatomaceous earth), the filtercake is washed with ethanol and the filtrate is concentrated using a rotary evaporator.

後処理

  1. filtrationThe suspension is filtered off through CELITE (diatomaceous earth)
  2. washthe filtercake is washed with ethanol
  3. concentrationthe filtrate is concentrated
  4. customa rotary evaporator

出典と根拠

ORDレコード
ord-e3cf80b818b84914a527d46ea5c07013
出典データセット
uspto-grants-2010_06
特許番号
US07737153B2

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