4-(2-Fluoro-4-nitrophenoxy)-1-benzofuran → 4-(1-Benzofuran-4-yloxy)-3-fluorophenylamine
反応式
[F:1][C:2]1[CH:17]=[C:16]([N+:18]([O-])=O)[CH:15]=[CH:14][C:3]=1[O:4][C:5]1[C:10]2[CH:11]=[CH:12][O:13][C:9]=2[CH:8]=[CH:7][CH:6]=1>C(O)C.O1CCCC1.[Pt](=O)=O>[O:13]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([O:4][C:3]3[CH:14]=[CH:15][C:16]([NH2:18])=[CH:17][C:2]=3[F:1])[C:10]=2[CH:11]=[CH:12]1参加物
4
実験手順
Under argon, 150 mg (0.55 mmol) of 4-(2-fluoro-4-nitrophenoxy)-1-benzofuran (from example XXII) are initially charged in 5 ml of ethanol/tetrahydrofuran (1:1), platinum(IV) oxide is added and the mixture is hydrogenated under atmospheric pressure for 2 hours. The suspension is filtered off through CELITE (diatomaceous earth), the filtercake is washed with ethanol and the filtrate is concentrated using a rotary evaporator.
後処理
- filtrationThe suspension is filtered off through CELITE (diatomaceous earth)
- washthe filtercake is washed with ethanol
- concentrationthe filtrate is concentrated
- customa rotary evaporator
出典と根拠
- ORDレコード
- ord-e3cf80b818b84914a527d46ea5c07013
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07737153B2
反応ノート
読み込み中…