Iodoethane → HCID 85875949、化合物
反応式
[CH:1]1[N:2]=[CH:3][N:4]2[C:9]=1[CH2:8][CH2:7][NH:6][C:5]2=[O:10].[CH2:11]([I:13])[CH3:12]>C(#N)C>[I-:13].[CH2:11]([N+:2]1[CH:1]=[C:9]2[N:4]([C:5](=[O:10])[NH:6][CH2:7][CH2:8]2)[CH:3]=1)[CH3:12]参加物
4
反応条件
- 温度
- 120 °C
実験手順
7,8-Dihydro-6H-imidazo[1,5-c]pyrimidin-5-one (1.00 g, 7.30 mmol) and ethyl iodide (3.42 g, 21.90 mmol) are placed in a 10-20 mL microwave vial. Acetonitrile (10 mL) is added and the reaction mixture is heated to 120° C. using microwave radiation. The reaction is shown to be complete by NMR after 1 hour. The crystalline material is filtered off and washed with ice-cold acetonitrile to give the title compound. 1H nmr (MeOD, 400 MHz); 7.60 (s, 1H), 4.35 (q, 2H), 3.65 (t, 2H), 3.15 (t, 2H), 1.60 (t, 3H).
後処理
- filtrationThe crystalline material is filtered off
- washwashed with ice-cold acetonitrile
出典と根拠
- ORDレコード
- ord-049e43d6b51c44ba9f23682b8a8832fd
- 出典データセット
- uspto-grants-2012_02
- 特許番号
- US08114877B2
反応ノート
読み込み中…