Ethyl Acetate → 4-(4-Amino-2-chlorophenoxy)-2-fluorobenzonitrile

HRID 16426

反応式

HRID 16426 の反応式
[F:1][C:2]1[CH:9]=[C:8](F)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[Cl:11][C:12]1[CH:13]=[C:14]([CH:16]=[CH:17][C:18]=1[OH:19])[NH2:15].C(=O)([O-])[O-].[K+].[K+].C(OCC)(=O)C>C(#N)C>[NH2:15][C:14]1[CH:16]=[CH:17][C:18]([O:19][C:8]2[CH:7]=[CH:6][C:3]([C:4]#[N:5])=[C:2]([F:1])[CH:9]=2)=[C:12]([Cl:11])[CH:13]=1

参加物

6

反応物 4

HCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 775452,4-DifluorobenzonitrileHCID 775784-Amino-2-chlorophenol

生成物 1

HCID 179793474-(4-Amino-2-chlorophenoxy)-2-fluorobenzonitrile

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

2.00 g (14.4 mmol) of 2,4-difluorobenzonitrile, 2.06 g (14.4 mmol) of 3-chloro-4-hydroxyaniline and 3.97 g (28.8 mmol) of potassium carbonate in 20 ml of acetonitrile are heated at RF for one hour. Ethyl acetate is added, the mixture is filtered and the solvent is removed under reduced pressure. The residue is purified by column chromatography (silica gel 60), giving the product which is a regioisomer mixture with a ratio of 62:38.

後処理

  1. filtrationthe mixture is filtered
  2. customthe solvent is removed under reduced pressure
  3. customThe residue is purified by column chromatography (silica gel 60)
  4. customgiving the product which

出典と根拠

ORDレコード
ord-469b7561ac284cd882eeac1cf9b3c0ae
出典データセット
uspto-grants-2010_06
特許番号
US07737153B2

関連ノート

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