反応式
[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH:12]=[C:13]([O:15][CH2:16][CH2:17][CH2:18][C:19]2[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=2)[CH:14]=1)[C:8]([O:10]C)=[O:9])([CH3:3])[CH3:2]>C1COCC1.CO.[OH-].[Na+]>[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH:12]=[C:13]([O:15][CH2:16][CH2:17][CH2:18][C:19]2[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=2)[CH:14]=1)[C:8]([OH:10])=[O:9])([CH3:3])[CH3:2]参加物
5
実験手順
Methyl 3-isopropoxy-5-(3-pyridin-3-ylpropoxy)benzoate (2.70 g) was dissolved in a mixed solvent of THF (30 ml) and methanol (30 ml), and 1N aqueous sodium hydroxide solution (25 ml) was added to the mixed solution. The mixture was stirred overnight at room temperature and concentrated under reduced pressure to dryness. 1N Aqueous hydrochloric acid solution (25 ml) was added thereto, and the precipitated crystals were collected by filtration and washed with water to give 3-isopropoxy-5-(3-pyridin-3-ylpropoxy)benzoic acid (1.55 g, 60%) as colorless crystals.
後処理
- additionwas added to the mixed solution
- concentrationconcentrated under reduced pressure to dryness
- addition1N Aqueous hydrochloric acid solution (25 ml) was added
- filtrationthe precipitated crystals were collected by filtration
- washwashed with water
出典と根拠
- ORDレコード
- ord-41d24c51cc214bbd9ccdddf2cfe23458
- 出典データセット
- uspto-grants-2012_02
- 特許番号
- US08124617B2
関連ノート
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