6-Nitro-1-pyrimidin-5-ylmethyl-1H-indole → 1-Pyrimidin-5-ylmethyl-1H-indol-6-ylamine

HRID 1645185ノート

反応式

HRID 1645185 の反応式
[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([CH:8]=[CH:9][N:10]2[CH2:13][C:14]2[CH:15]=[N:16][CH:17]=[N:18][CH:19]=2)=[CH:6][CH:5]=1)([O-])=O>C1COCC1.C(O)(C)C.[Pd]>[N:16]1[CH:15]=[C:14]([CH2:13][N:10]2[C:11]3[C:7](=[CH:6][CH:5]=[C:4]([NH2:1])[CH:12]=3)[CH:8]=[CH:9]2)[CH:19]=[N:18][CH:17]=1

参加物

5

反応物 1

HCID 667755866-Nitro-1-pyrimidin-5-ylmethyl-1H-indole

生成物 1

HCID 667756801-Pyrimidin-5-ylmethyl-1H-indol-6-ylamine

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 3776Isopropanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

6-Nitro-1-pyrimidin-5-ylmethyl-1H-indole (4.1 g, 16.1 mmol) was dissolved in 100 mL of THF and 100 mL of isopropanol. Pd/C (2 g) was added and the mixture was stirred under an H2-atmosphere (balloon) for 2 hours. The mixture was filtered over Celite and washed with ethyl acetate affording the title compound after concentration (3.5 g, 15.6 mmol, 97%).

後処理

  1. filtrationThe mixture was filtered over Celite
  2. washwashed with ethyl acetate affording the title compound
  3. concentrationafter concentration (3.5 g, 15.6 mmol, 97%)

出典と根拠

ORDレコード
ord-5c01707a66794f28bb16f46f07b098e8
出典データセット
uspto-grants-2012_02
特許番号
US08124647B2

反応ノート

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