1,1'-Carbonyldiimidazole → HCID 10465394、化合物

HRID 1646751ノート

反応式

HRID 1646751 の反応式
[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:4][C:3]=1[CH2:11][CH2:12][NH2:13].[C:14](N1C=CN=C1)(N1C=CN=C1)=[O:15]>O1CCCC1>[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]2[C:14](=[O:15])[NH:13][CH2:12][CH2:11][C:3]=12

参加物

4

反応物 2

HCID 682631,1'-CarbonyldiimidazoleHCID 118195262-(3-methyl-1H-indol-2-yl)ethan-1-amine

生成物 1

HCID 10465394HCID 10465394、化合物収率 40.5%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
100 °C

実験手順

To a solution of 2-(3-methylindol-2-yl)ethylamine (1.74 g) in tetrahydrofuran (200 ml) at room temperature was added 1,1'-carbonyldiimidazole (1.6 g) in small portions. After one hour of stirring, the reaction mixture was evaporated in vacuo. The residue was dissolved in toluene and the solution was evaporated in vacuo. The oil obtained was heated at 100° C. for 40 minutes and then cooled. Purification of the residue with silica gel column chromatography (chloroform) gave 3,4-dihydro-5-methylpyrimido[1,6-a]indol-1(2H)-one (0.8 g).

後処理

  1. customthe reaction mixture was evaporated in vacuo
  2. dissolutionThe residue was dissolved in toluene
  3. customthe solution was evaporated in vacuo
  4. customThe oil obtained
  5. temperaturecooled
  6. customPurification of the residue with silica gel column chromatography (chloroform)

出典と根拠

ORDレコード
ord-9f6f8476120f4adb95651dbc5db63a48
出典データセット
uspto-grants-1993_01
特許番号
US05180728

反応ノート

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