Trifluoroacetic acid → 2-Amino-N-(1H-benzimidazol-2-ylmethyl)-3-methylpentanamide tris(trifluoroacetate)

HRID 1647346

反応式

HRID 1647346 の反応式
CC(OC(=O)[NH:7][CH:8]([C:13]([NH:15][CH2:16][C:17]1[NH:21][C:20]2[CH:22]=[CH:23][CH:24]=[CH:25][C:19]=2[N:18]=1)=[O:14])[CH:9]([CH3:12])[CH2:10][CH3:11])(C)C.[F:27][C:28]([F:33])([F:32])[C:29]([OH:31])=[O:30]>C(Cl)Cl>[F:27][C:28]([F:33])([F:32])[C:29]([OH:31])=[O:30].[F:27][C:28]([F:33])([F:32])[C:29]([OH:31])=[O:30].[F:27][C:28]([F:33])([F:32])[C:29]([OH:31])=[O:30].[NH2:7][CH:8]([CH:9]([CH3:12])[CH2:10][CH3:11])[C:13]([NH:15][CH2:16][C:17]1[NH:18][C:19]2[CH:25]=[CH:24][CH:23]=[CH:22][C:20]=2[N:21]=1)=[O:14]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acid2 回HCID 67747066[1-[[(1H-Benzimidazol-2-ylmethyl)amino]carbonyl]-2-methylbutyl]carbamic acid 1,1-dimethylethyl ester

生成物 1

HCID 220685082-Amino-N-(1H-benzimidazol-2-ylmethyl)-3-methylpentanamide tris(trifluoroacetate)

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The title compound is prepared by the procedure of Example 2 using 0.588 g of product from Example 11 in 6 ml of methylene chloride and 1.3 g of trifluoroacetic acid (TFA). The resulting desired intermediate is used as is in the next reaction. The 1HNMR indicates the correct product with associated TFA molecules.

後処理

  1. customas is in the next reaction

出典と根拠

ORDレコード
ord-c1c35f840070428b904dbe90e280737a
出典データセット
uspto-grants-1995_07
特許番号
US05430150

関連ノート

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