Hydrochloric Acid → Isopilocarpic Acid Sodium Salt

HRID 1648495ノート

反応式

HRID 1648495 の反応式
[CH3:1][CH2:2][C@@H:3]1[C:7](=[O:8])[O:6][CH2:5][C@@H:4]1[CH2:9][C:10]1[N:14]([CH3:15])[CH:13]=[N:12][CH:11]=1.Cl.[OH-:17].[Na+:18].Cl>O>[CH3:1][CH2:2][C@@H:3]([C:7]([O-:6])=[O:8])[C@H:4]([CH2:5][OH:17])[CH2:9][C:10]1[N:14]([CH3:15])[CH:13]=[N:12][CH:11]=1.[Na+:18]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 5909Pilocarpine HydrochlorideHCID 14798Sodium Hydroxide

生成物 1

HCID 71749484Isopilocarpic Acid Sodium Salt

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
0 °C

実験手順

Pilocarpine hydrochloride (3.92 g; 16.00 moles) was dissolved in distilled water (4 ml) and the solution was cooled to about 0° C. To the solution 18 ml of ice cold 2M NaOH were added in four portions. The solution was left standing at about 0° C. for one hour. After neutralizing excess NaOH with 5 ml of 1M HCl, the solution was evaporated under reduced pressure. The residue was dissolved in 60 ml of absolute ethanol and mixed for 10 minutes at 60° C. After cooling to 4° C. undissolved NaCl was removed by filtration. The filtrate was evaporated under reduced pressure, whereby 3.93 g of sodium pilocarpate were obtained as a white, extremely hygroscopic substance.

後処理

  1. waitThe solution was left
  2. customthe solution was evaporated under reduced pressure
  3. dissolutionThe residue was dissolved in 60 ml of absolute ethanol
  4. additionmixed for 10 minutes at 60° C
  5. temperatureAfter cooling to 4° C. undissolved NaCl
  6. customwas removed by filtration
  7. customThe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-d37ed0d5c9d84a7dab62e0522dee2f7f
出典データセット
uspto-grants-1995_07
特許番号
US05436350

反応ノート

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