Sodium Acetate → 1-(2-Aminothiazol-4-yl)-1-propencarboxylic acid ethyl ester

HRID 1649413

反応式

HRID 1649413 の反応式
[CH2:1]([O:3][C:4](=[O:12])[C:5](=[CH:10][CH3:11])[C:6](=O)[CH2:7]Cl)[CH3:2].C([O-])(=O)C.[Na+].[NH2:18][C:19]([NH2:21])=[S:20]>O1CCCC1.O>[CH2:1]([O:3][C:4]([C:5]([C:6]1[N:18]=[C:19]([NH2:21])[S:20][CH:7]=1)=[CH:10][CH3:11])=[O:12])[CH3:2]

参加物

6

反応物 3

HCID 517045Sodium AcetateHCID 2723790ThioureaHCID 54518096Ethyl 2-ethylidene-4-chloro-3-oxobutyrate

生成物 1

HCID 544043711-(2-Aminothiazol-4-yl)-1-propencarboxylic acid ethyl ester

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

to a solution of 190 g of the product of example 81 in 400 ml tetrahydrofuran were added first a solution of 82 g sodium acetate in 150 ml of water and then 76 g thiourea. The solution was stirred at room temperature for 20 hours, then the THF was distilled off and acetic acid ethyl ester was added to the residue.

後処理

  1. distillationthe THF was distilled off
  2. additionacetic acid ethyl ester was added to the residue

出典と根拠

ORDレコード
ord-9b4705d37edf4c80b2ad9f87b172ad31
出典データセット
uspto-grants-1983_11
特許番号
US04416880

関連ノート

読み込み中…