Sodium Iodide → HCID 14726173、化合物

HRID 1650352ノート

反応式

HRID 1650352 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9](=[O:12])[CH2:10]Cl.[Na+].[I-:14]>CC#N>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9](=[O:12])[CH2:10][I:14]

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 124777791-(2-Amino-5-chlorophenyl)-2-chloroethan-1-one

生成物 1

HCID 14726173HCID 14726173、化合物収率 99.2%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a solution of 11.208 g (54.93 mM) of 2'-amino-2,5'-di-chloroacetophenone in 281 ml of CH3CN is added 24.7 g (165 mM) of NaI, and the mixture is stirred at room temperature for 2.5 hr. and concentrated under reduced pressure. The residue is dissolved in ethyl acetate, washed with aqueous Na2S2O3, and brine in order, dried and concentrated to give 16.1 g (Yield: 99.2%) of 2'-amino-5'-chloro-2-iodoacetophenone as crystals.

後処理

  1. concentrationand concentrated under reduced pressure
  2. dissolutionThe residue is dissolved in ethyl acetate
  3. washwashed with aqueous Na2S2O3, and brine in order
  4. customdried
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-50603343b20340f6b743e3d1ddc51f19
出典データセット
uspto-grants-1990_05
特許番号
US04923984

反応ノート

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