Sodium Iodide → HCID 19853685、化合物

HRID 1650354ノート

反応式

HRID 1650354 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9](=[O:12])[CH2:10]Cl.[Na+].[I-:14]>CC#N>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9](=[O:12])[CH2:10][I:14]

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 107500971-(2-Amino-5-fluorophenyl)-2-chloroethan-1-one

生成物 1

HCID 19853685HCID 19853685、化合物収率 85.9%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a solution of 23.463 g (125.069 mM) of 2'-amino-2-chloro-5'-fluoroacetophenone in 436 ml of CH3CN is added 56.2 g (375.2 mM) of NaI, and the mixture is stirred at room temperature for 45 min. and concentrated under reduced pressure. The resulting residue is dissolved in ethyl acetate, washed with aqueous Na2S2O3, and brine in order, dried and concentrated to give 29.97 g (Yield: 85.9%) of 2'-amino-5'-fluoro-2-iodoacetophenone as yellow crystals.

後処理

  1. concentrationconcentrated under reduced pressure
  2. dissolutionThe resulting residue is dissolved in ethyl acetate
  3. washwashed with aqueous Na2S2O3, and brine in order
  4. customdried
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-a9323496a42543e7898a68bee400daa5
出典データセット
uspto-grants-1990_05
特許番号
US04923984

反応ノート

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