Chloroacetyl chloride → 5-t-butyl-2-methoxy-3-(chloroacetamido) phenyl N-t-butylsulfonamide

HRID 1651477ノート

反応式

HRID 1651477 の反応式
[Cl:1][CH2:2][C:3](Cl)=[O:4].[C:6]([C:10]1[CH:11]=[C:12]([NH2:26])[C:13]([O:24][CH3:25])=[C:14]([S:16]([NH:19][C:20]([CH3:23])([CH3:22])[CH3:21])(=[O:18])=[O:17])[CH:15]=1)([CH3:9])([CH3:8])[CH3:7].C(N(C(C)C)CC)(C)C>ClCCl>[C:6]([C:10]1[CH:11]=[C:12]([NH:26][C:3](=[O:4])[CH2:2][Cl:1])[C:13]([O:24][CH3:25])=[C:14]([S:16]([NH:19][C:20]([CH3:23])([CH3:22])[CH3:21])(=[O:17])=[O:18])[CH:15]=1)([CH3:9])([CH3:7])[CH3:8]

参加物

5

反応物 3

HCID 6577Chloroacetyl chlorideHCID 81531DiisopropylethylamineHCID 150295865-t-butyl-2-methoxy-3-aminophenyl N-t-butyl sulfonamide

生成物 1

HCID 150295875-t-butyl-2-methoxy-3-(chloroacetamido) phenyl N-t-butylsulfonamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A solution of chloroacetyl chloride (4.4 ml) in dichloromethane (40 ml) was added dropwise to a cooled and stirred solution of 5-t-butyl-2-methoxy-3-aminophenyl N-t-butyl-sulfonamide (15.6 g) and diisopropylethylamine (9.5 ml) in dichloromethane (100 ml). The solution was left standing at ambient temperature for 2 hours and then washed with a 2% solution of citric acid. The organic phase was dried and evaporated. Recrytallization from aqueous ethanol gave the title compound (16.4 g).

後処理

  1. temperaturea cooled
  2. waitThe solution was left
  3. washwashed with a 2% solution of citric acid
  4. customThe organic phase was dried
  5. customevaporated

出典と根拠

ORDレコード
ord-979e8240d54b4415a395bd82d5be5d51
出典データセット
uspto-grants-1990_05
特許番号
US04929269

反応ノート

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