Ethylene Glycol → HCID 14770852、化合物

HRID 1651583ノート

反応式

HRID 1651583 の反応式
[Br:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([CH:9]2[CH2:13][CH2:12][C:11](=[O:14])[CH2:10]2)=[C:4]([F:15])[CH:3]=1.[CH2:16](O)[CH2:17][OH:18]>C1(C)C=CC(S(O)(=O)=O)=CC=1.C1(C)C=CC=CC=1>[Br:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([CH:9]2[CH2:13][CH2:12][C:11]3([O:18][CH2:17][CH2:16][O:14]3)[CH2:10]2)=[C:4]([F:15])[CH:3]=1

参加物

5

反応物 2

HCID 174Ethylene GlycolHCID 14770833HCID 14770833、化合物

生成物 1

HCID 14770852HCID 14770852、化合物収率 88.4%

試薬・触媒・溶媒 2

HCID 6101p-Toluenesulfonic acid触媒HCID 1140Toluene溶媒

実験手順

A solution of 27.5 g (0.1 mol) of 3-(4-bromo-2,5-difluorophenyl)cyclopentanone, 18.6 g (0.3 mol) of ethylene glycol, 1 g of p-toluenesulfonic acid and 500 ml of toluene was heated at reflux with a Dean-Stark trap for 18 hours. The cooled solution was washed with 5% sodium bicarbonate solution (2×250 ml), dried (MgSO4), and evaporated in vacuo to give 28.2 g of the title compound which was used without further purification.

後処理

  1. temperatureat reflux with a Dean-Stark trap for 18 hours
  2. washThe cooled solution was washed with 5% sodium bicarbonate solution (2×250 ml)
  3. dry with materialdried (MgSO4)
  4. customevaporated in vacuo

出典と根拠

ORDレコード
ord-6b8b2102aa904a7284c45b29ae2e8129
出典データセット
uspto-grants-1990_05
特許番号
US04929613

反応ノート

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