Trifluoroacetic acid → 1-Propyne, 3-(1-ethoxyethoxy)-
反応式
[CH2:1]([OH:4])[C:2]#[CH:3].[CH:5]([O:7][CH2:8][CH3:9])=[CH2:6].FC(F)(F)C(O)=O.C(=O)([O-])[O-].[Na+].[Na+]>>[CH2:5]([O:7][CH:8]([O:4][CH2:1][C:2]#[CH:3])[CH3:9])[CH3:6]参加物
5
実験手順
A solution of 20 g (0.36 mol) of 2-propyn-1-ol 1n 637 ml (6.66 mol) of ethyl vinyl ether was treated at 0° under argon with 1.27 ml (16.7 mmol) of trifluoroacetic acid and subsequently stirred at room temperature for 65 hours. 1.3 g of sodium carbonate were added, the react ion mixture was stirred at room temperature for a further 30 minutes and concentrated on a rotary evaporator. Distillation of the residue under reduced pressure Yielded 1-(1-ethoxyethoxy)-2-propyne of boiling point 55°/30 mmHg. MS: 127 (M-H) m/e.
後処理
- stirringthe react ion mixture was stirred at room temperature for a further 30 minutes
- concentrationconcentrated on a rotary evaporator
- distillationDistillation of the residue under reduced pressure
出典と根拠
- ORDレコード
- ord-ec63efba3fea45e1bdae26c6eefae67c
- 出典データセット
- uspto-grants-1990_05
- 特許番号
- US04929741
反応ノート
読み込み中…