Thionyl Chloride → 4-(Chloromethyl)-2-cyclopropylthiazole hydrochloride

HRID 1654212ノート

反応式

HRID 1654212 の反応式
[CH:1]1([C:4]2[S:5][CH:6]=[C:7]([CH2:9]O)[N:8]=2)[CH2:3][CH2:2]1.S(Cl)([Cl:13])=O>C(Cl)(Cl)Cl>[ClH:13].[CH:1]1([C:4]2[S:5][CH:6]=[C:7]([CH2:9][Cl:13])[N:8]=2)[CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 20079576(2-Cyclopropylthiazol-4-yl)methanol

生成物 1

HCID 187591664-(Chloromethyl)-2-cyclopropylthiazole hydrochloride

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

In chloroform (10 ml) was dissolved 2-cyclopropyl-4-hydroxymethylthiazole (0.9 g), to which was added dropwise, under ice-cooling, thionyl chloride (0.68 ml), followed by stirring for 30 minutes at room temperature. Excess thionyl chloride was distilled off under reduced pressure. To the residue was added diethyl ether to yield 2-cyclopropyl-4-chloromethyl thiazole hydrochloride (1.1 g) as pale brown powder. m.p. 108°-110° C.

後処理

  1. additionto which was added dropwise, under ice-
  2. temperaturecooling
  3. distillationExcess thionyl chloride was distilled off under reduced pressure
  4. additionTo the residue was added diethyl ether

出典と根拠

ORDレコード
ord-21dbd786b3184c6bb3ae790f12765813
出典データセット
uspto-grants-1995_04
特許番号
US05405861

反応ノート

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