反応式
C[Si](C)(C)N[Si](C)(C)C.[Li].[O:11]1[CH:15]=[CH:14][CH:13]=[C:12]1[C:16]#[CH:17].[CH:18](=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>O1CCCC1>[O:11]1[CH:15]=[CH:14][CH:13]=[C:12]1[C:16]#[C:17][CH:18]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[OH:25]参加物
5
実験手順
Place lithium hexamethyldisilazane (3 mL of a 1M solution in tetrahydrofuran, 3 mmol) under argon atmosphere and cool to 0° C. Add 2-furanylacetylene (276 mg, 3 mmol) in tetrahydrofuran (20 mL) and stir at 0° C. until anion formation is complete. Add a solution of benzaldehyde (297 mg, 2.8 mmol) in tetrahydrofuran, remove the ice bath and stir at room temperature until the reaction is complete. Pour onto ethyl ether and water, separate the organic layer and dry (MgSO4). Filter and evaporate the solvent in vacuo. Purify by silica gel chromatography to yield the title compound.
後処理
- customremove the ice bath
- additionPour onto ethyl ether and water
- customseparate the organic layer
- dry with materialdry (MgSO4)
- filtrationFilter
- customevaporate the solvent in vacuo
- customPurify by silica gel chromatography
出典と根拠
- ORDレコード
- ord-2e9f376ed6604e7fa0f13a36388ca523
- 出典データセット
- uspto-grants-1995_04
- 特許番号
- US05409942
関連ノート
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