Dichloromethane → 1-Phenyl-3-(2-furanyl)-2-propyne-1-one

HRID 1654777

反応式

HRID 1654777 の反応式
[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=O.[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1.C(Cl)Cl.[O:25]1[CH:29]=[CH:28][CH:27]=[C:26]1[C:30]#[C:31][CH:32]([C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[OH:33]>C(OCC)C>[C:34]1([C:32](=[O:33])[C:31]#[C:30][C:26]2[O:25][CH:29]=[CH:28][CH:27]=2)[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1

参加物

5

反応物 3

HCID 6344DichloromethaneHCID 2724130Cornforth reagentHCID 20076917alpha-[(2-Furanyl)ethynyl]-benzenemethanol

生成物 1

HCID 144017341-Phenyl-3-(2-furanyl)-2-propyne-1-one

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

Place pyridinium dichromate (0.75 g, 2 mmol) and methylene chloride (15 mL) under argon atmosphere and cool to 0° C. Add α-[(2-furanyl)ethynyl]-benzenemethanol (297 mg, 1.5 mmol). Stir overnight while slowly warming to room temperature. Dilute with ethyl ether and filter the chromium salts. Purify by silica gel chromatography to give the title compound.

後処理

  1. filtrationfilter the chromium salts
  2. customPurify by silica gel chromatography

出典と根拠

ORDレコード
ord-a42f66b7f987487399e9614f7813cf37
出典データセット
uspto-grants-1995_04
特許番号
US05409942

関連ノート

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