Water → 2-(2,3-dihydro-1H-inden-2-yl)ethanol

HRID 1654941ノート

反応式

HRID 1654941 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].C[O:8][C:9](=O)[CH2:10][CH:11]1[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12]1.O.[OH-].[Na+]>O1CCCC1>[CH2:19]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12][CH:11]1[CH2:10][CH2:9][OH:8]

参加物

6

反応物 4

HCID 962Water2 回HCID 14798Sodium HydroxideHCID 14090225Methyl (2,3-dihydro-1H-inden-2-yl)acetateHCID 21226445Aluminium lithium hydride

生成物 1

HCID 103520002-(2,3-dihydro-1H-inden-2-yl)ethanol収率 100%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

1.02 g (26.8 mmol) of lithium aluminum hydride was suspended in 100 ml of tetrahydrofuran, to which was added dropwise a solution of 10 ml tetrafuran containing 5.06 g (26.6 mmol) of methyl(indan-2-yl)acetate under ice-cooling. After completion of the addition, stirring was continued for 1 hour, during which 1 ml water, 1 ml of 15% sodium hydroxide and 3 ml water were added dropwise in this order for decomposing the excessive reducing agent. The solid matter was removed by filtration, the filtrate was condensed and the residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:4) to obtain 4.30 g of a colorless oil. Yield: 100%

後処理

  1. temperaturecooling
  2. additionAfter completion of the addition
  3. additionwere added dropwise in this order
  4. customThe solid matter was removed by filtration
  5. customcondensed
  6. customthe residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:4)

出典と根拠

ORDレコード
ord-f03b3b53196c4a62a31e3c2dc29dff39
出典データセット
uspto-grants-1995_04
特許番号
US05409956

反応ノート

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