Thionyl Chloride → 5-Bromo-4-amino-2-chloromethylpyridine hydrochloride

HRID 1655204ノート

反応式

HRID 1655204 の反応式
[Br:1][C:2]1[C:3]([NH2:10])=[CH:4][C:5]([CH2:8]O)=[N:6][CH:7]=1.S(Cl)([Cl:13])=O>C(Cl)(Cl)Cl>[ClH:13].[Br:1][C:2]1[C:3]([NH2:10])=[CH:4][C:5]([CH2:8][Cl:13])=[N:6][CH:7]=1

参加物

4

反応物 2

HCID 24386Thionyl Chloride2 回HCID 17992217HCID 17992217、化合物

生成物 1

HCID 179922125-Bromo-4-amino-2-chloromethylpyridine hydrochloride

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

5 -Bromo-4 -amino-2 -hydroxymethylpyridine (0.60 g, 0.003 M) in chloroform (15 ml) was cooled to -10 ° and thionyl chloride (0.64 ml, 1.05 g, 0.0089 M) in chloroform (5 ml) added dropwise over 20 minutes so that the temperature of the reaction mixture did not rise above -10°. The reaction mixture was stirred for 1 hour at -10 ° and then allowed to warm to room temperature and stirred for 21 hours (if the reaction is not complete at this stage, further portions of thionyl chloride can be added (at -10 °), followed by reflux if necessary).

後処理

  1. customdid not rise above -10°
  2. stirringstirred for 21 hours (if the reaction
  3. additioncan be added (at -10 °)
  4. temperatureby reflux if necessary)

出典と根拠

ORDレコード
ord-1470f9b593de4137ba67645b6e7f5b0c
出典データセット
uspto-grants-1993_10
特許番号
US05250527

反応ノート

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