Acrylonitrile → 1-(4-Benzyloxy benzoyl) 2-(2-cyano ethyl) hydrazine

HRID 1655357ノート

反応式

HRID 1655357 の反応式
[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][C:12]([C:13]([NH:15][NH2:16])=[O:14])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:19](#[N:22])[CH:20]=[CH2:21]>C(O)CC>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]([NH:15][NH:16][CH2:21][CH2:20][C:19]#[N:22])=[O:14])=[CH:17][CH:18]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 7855Acrylonitrile2 回HCID 15264864-(Benzyloxy)benzohydrazide

生成物 1

HCID 110984481-(4-Benzyloxy benzoyl) 2-(2-cyano ethyl) hydrazine収率 88%

試薬・触媒・溶媒 1

HCID 10311-Propanol溶媒

実験手順

To a solution of 100 mmoles of (4-benzyloxy benzoyl) hydrazine in 200 ml of 1-propanol, 100 mmoles of acrylonitrile are added and the mixture is heated for 24 hours at reflux. Then 50 mmoles of acrylonitrile are added and the heating is continued at reflux for 24 hours. After cooling, the product is filtered and recrystallized in a water-ethanol mixture and 26 g (yield: 88%) of the expected product were obtained.

後処理

  1. temperaturethe mixture is heated for 24 hours
  2. temperatureat reflux
  3. temperatureat reflux for 24 hours
  4. temperatureAfter cooling
  5. filtrationthe product is filtered
  6. customrecrystallized in a water-ethanol mixture

出典と根拠

ORDレコード
ord-1359b3e2a3d54ce39397bf101b45e1cf
出典データセット
uspto-grants-1993_10
特許番号
US05250551

反応ノート

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