Methane → 4-(4-Aminophenoxy)phenol

HRID 1655444ノート

反応式

HRID 1655444 の反応式
[OH:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.C.C1COCC1.[H][H]>[Pt].C(OCC)(=O)C>[NH2:13][C:10]1[CH:11]=[CH:12][C:7]([O:6][C:5]2[CH:16]=[CH:17][C:2]([OH:1])=[CH:3][CH:4]=2)=[CH:8][CH:9]=1

参加物

7

反応物 4

HCID 297MethaneHCID 8028TetrahydrofuranHCID 1524504-(4-Nitrophenoxy)phenolHCID 178418361HCID 178418361、化合物

生成物 1

HCID 152173634-(4-Aminophenoxy)phenol収率 96.2%

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 8857Ethyl Acetate溶媒

実験手順

1-(4-Hydroxyphenoxy)-4-nitrobenzene X (8.93 g, 38.62 mmol), 0.5% platinum catalyst on activated charcoal (1.5 g), THF (100 mL), and ethyl acetate (20 mL) were charged into a 250 mL hydrogenation vessel. Hydrogenation was carried out under 60 psi of hydrogen at room temperature for 16 hr. The reaction mixture was filtered and the organic solvents were removed under reduced pressure at 40° C. to give 4-(4-aminophenoxy)phenol XI (8.10 g, 96.2% yield), mp 130°-4° C. The IR and 1H-NMR spectra agreed with the assigned structure.

後処理

  1. filtrationThe reaction mixture was filtered
  2. customthe organic solvents were removed under reduced pressure at 40° C.

出典と根拠

ORDレコード
ord-79fa8365654d416986b231c4af5c4489
出典データセット
uspto-grants-1993_10
特許番号
US05250667

反応ノート

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