Diisopropyl Ether → 2-Amino-5-bromo-4-methyl-1,3-thiazole hydrochloride

HRID 1656934ノート

反応式

HRID 1656934 の反応式
[ClH:1].[NH2:2][C:3]1[S:4][CH:5]=[C:6]([CH3:8])[N:7]=1.[Br:9]N1C(=O)CCC1=O.C(OC(C)C)(C)C>C(O)(=O)C>[ClH:1].[NH2:2][C:3]1[S:4][C:5]([Br:9])=[C:6]([CH3:8])[N:7]=1

参加物

5

反応物 3

HCID 7914Diisopropyl EtherHCID 67184N-bromobutanimideHCID 802402-Thiazolamine, 4-methyl-, hydrochloride (1:1)

生成物 1

HCID 189547282-Amino-5-bromo-4-methyl-1,3-thiazole hydrochloride収率 89.7%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a solution of 2-amino-4-methylthiazole hydrochloride (3.0 g) in acetic acid (20 ml) was added once N-bromosuccinimide (4.0 g) at room temperature with stirring. The mixture was stirred at room temperature for 1.5 hours and the reaction mixture was poured into isopropyl ether under ice cooling. The precipitates were collected by filtration, washed with ethyl ether and dried in vacuo to give 2-amino-5-bromo-4-methylthiazole hydrochloride (4.1 g, yield: 89.1%).

後処理

  1. stirringThe mixture was stirred at room temperature for 1.5 hours
  2. filtrationThe precipitates were collected by filtration
  3. washwashed with ethyl ether
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-5e4a4947972144dcb8057233d69acbbd
出典データセット
uspto-grants-1993_10
特許番号
US05256675

反応ノート

読み込み中…