Ethanol → 2-Formylamino-4-(4-aminophenylthiomethyl)thiazole

HRID 1656971ノート

反応式

HRID 1656971 の反応式
[CH:1]([NH:3][C:4]1[S:5][CH:6]=[C:7]([CH2:9][S:10][C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=2)[N:8]=1)=[O:2].[Cl-].[NH4+].C(O)C.O>O1CCCC1.[Fe]>[CH:1]([NH:3][C:4]1[S:5][CH:6]=[C:7]([CH2:9][S:10][C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=2)[N:8]=1)=[O:2]

参加物

7

反応物 4

HCID 702EthanolHCID 962WaterHCID 25517Ammonium ChlorideHCID 15729170HCID 15729170、化合物

生成物 1

HCID 157291712-Formylamino-4-(4-aminophenylthiomethyl)thiazole収率 81%

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a mixture of 2-formylamino-4-(4-nitrophenylthiomethyl)thiazole (2.2 g) and ammonium chloride (0.5 g) in a mixture of tetrahydrofuran (30 ml), ethanol (50 ml) and water (10 ml) was added portionwise the iron powder at 80° C. with stirring. The mixture was refluxed for 2 hours with stirring. The reaction mixture was filtered by suction and the residue was triturated with water. The precipitates were collected by filtration, washed with water and dried in vacuo to give 2-formylamino-4-(4-aminophenylthiomethyl)thiazole (1.6 g, yield: 81%). mp: 180°-182° C.

後処理

  1. temperatureThe mixture was refluxed for 2 hours
  2. stirringwith stirring
  3. filtrationThe reaction mixture was filtered by suction
  4. customthe residue was triturated with water
  5. filtrationThe precipitates were collected by filtration
  6. washwashed with water
  7. customdried in vacuo

出典と根拠

ORDレコード
ord-8edd794016874f1ba35246534b43a515
出典データセット
uspto-grants-1993_10
特許番号
US05256675

反応ノート

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