Pyridine → 2-(2-Fluoroacetamido)-N-(2-methylphenyl)-5-nitrobenzamide

HRID 1658722ノート

反応式

HRID 1658722 の反応式
[NH2:1][C:2]1[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][C:3]=1[C:4]([NH:6][C:7]1[C:8]([CH3:13])=[CH:9][CH:10]=[CH:11][CH:12]=1)=[O:5].N1C=CC=CC=1.[F:27][CH2:28][C:29](Cl)=[O:30]>O1CCCC1>[F:27][CH2:28][C:29]([NH:1][C:2]1[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][C:3]=1[C:4]([NH:6][C:7]1[C:8]([CH3:13])=[CH:9][CH:10]=[CH:11][CH:12]=1)=[O:5])=[O:30]

参加物

5

反応物 3

HCID 1049PyridineHCID 9663Fluoroacetyl chlorideHCID 124873692-Amino-N-(2-methylphenyl)-5-nitrobenzamide

生成物 1

HCID 215254582-(2-Fluoroacetamido)-N-(2-methylphenyl)-5-nitrobenzamide収率 93.7%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

14.4 g(0.053 mol) of N-(2-amino-5-nitrobenzoyl)-o-toluidine and 6.3 g(0.08 mol) of pyridine are dissolved in 300 ml of tetrahydrofuran. 12.2 g(0.126 mol) of fluoroacetyl chloride are added to the solution for 10 minutes under ice-cooling. The solution is stirred at the same temperature for 30 minutes and then at room temperature for 2.5 hours. The reaction solution is allowed to stand at room temperature overnight. The crystalline precipitate is collected by filtration, washed with water and then dried. 16.4 g of N-(2-fluoroacetamido-5-nitrobenzoyl)-o-toluidine are obtained.

後処理

  1. temperaturecooling
  2. waitat room temperature for 2.5 hours
  3. waitto stand at room temperature overnight
  4. filtrationThe crystalline precipitate is collected by filtration
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-8f1f19b74be44caa9ca7c68e4adaf40e
出典データセット
uspto-grants-1976_06
特許番号
US03966731

反応ノート

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