Sodium Carbonate → 4-(N-methylanilino)-2-butanone oxime

HRID 1659591ノート

反応式

HRID 1659591 の反応式
Cl.[NH2:2][OH:3].[CH3:4][N:5]([CH2:12][CH2:13][C:14](=O)[CH3:15])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.C(=O)([O-])[O-].[Na+].[Na+]>O.C(O)C>[CH3:4][N:5]([CH2:12][CH2:13][C:14](=[N:2][OH:3])[CH3:15])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

参加物

6

反応物 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 114126874-(Methyl-phenyl-amino)-butan-2-one

生成物 1

HCID 867381524-(N-methylanilino)-2-butanone oxime

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

Add hydroxylamine hydrochloride (4.9 g=70 mmol) in 20 ml water to a solution of 4-(N-methylanilino)-2-butanone (12.4 g=70 mmol) and sodium carbonate (8.6 g=80 mmol) in 60 ml 50% ethanol. Stir for three days, concentrate and extract with ethyl acetate. Dry, concentrate and recrystallize from ether-hexane to obtain product having a melting point 46°-49° C.

後処理

  1. concentrationconcentrate
  2. extractionextract with ethyl acetate
  3. customDry
  4. concentrationconcentrate
  5. customrecrystallize from ether-hexane
  6. customto obtain product

出典と根拠

ORDレコード
ord-b893b9d7dc554144ad28d81d2556d762
出典データセット
uspto-grants-1981_12
特許番号
US04304790

反応ノート

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