Potassium Carbonate → HCID 20559535、化合物
反応式
[F:1][C:2]([F:7])([F:6])[C:3]([NH2:5])=[O:4].C(=O)([O-])[O-].[K+].[K+].[C:14]([O:22][C:23]1[CH:28]=[CH:27][C:26]([C:29](=[O:32])[CH2:30]Br)=[CH:25][C:24]=1[S:33][CH3:34])(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(#N)C>[C:14]([O:22][C:23]1[CH:28]=[CH:27][C:26]([C:29](=[O:32])[CH2:30][NH:5][C:3](=[O:4])[C:2]([F:7])([F:6])[F:1])=[CH:25][C:24]=1[S:33][CH3:34])(=[O:21])[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1参加物
5
実験手順
Add trifluoroacetamide (6.8 g=60 mmol) and potassium carbonate (8.0 g=60 mmol) to a solution of 4'-benzoyloxy-3'-methylthio-2-bromoacetophenone (11.0 g=30 mmol) in 200 ml acetonitrile. Reflux for 16 hours, allow to cool, filter, and concentrate. Dissolve the residue in ethyl acetate, wash with 1.0 N sodium hydroxide, then water. Dry, concentrate and treat the residue with ether to obtain the product as a yellow solid.