Sodium hydride → HCID 24955304、化合物

HRID 1661466ノート

反応式

HRID 1661466 の反応式
[CH3:1][C@@H:2]1[C@@H:4]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:3]1[S:11]([CH3:14])(=[O:13])=[O:12].[F:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]2[C:30]3[C:25](=[CH:26][C:27]([SH:31])=[CH:28][CH:29]=3)[CH:24]=[N:23]2)=[CH:18][CH:17]=1.[H-].[Na+]>C1COCC1>[F:15][C:16]1[CH:17]=[CH:18][C:19]([N:22]2[C:30]3[C:25](=[CH:26][C:27]([S:31][C@H:4]([C:5]4[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=4)[C@@H:2]([NH:3][S:11]([CH3:14])(=[O:13])=[O:12])[CH3:1])=[CH:28][CH:29]=3)[CH:24]=[N:23]2)=[CH:20][CH:21]=1

参加物

5

反応物 3

HCID 24758Sodium hydrideHCID 16112501HCID 16112501、化合物HCID 593397121-(4-Fluorophenyl)-1H-indazole-5-thiol

生成物 1

HCID 24955304HCID 24955304、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To (2R,3R)-2-methyl-1-(methylsulfonyl)-3-phenylaziridine (38a, 0.03 g, 0.14 mmol) in THF (4 ml) was added 1-(4-Fluorophenyl)-1H-indazole-5-thiol (37c, 0.038 g, 0.16 mmol) and sodium hydride (5.11 mg, 0.21 mmol) on an ice bath with stirring. The ice bath was removed and the mixture was stirren at room temperature over night. The solvent was removed and the mixture was purified on HPLC. Yield 0.007 g (11%).

後処理

  1. customThe ice bath was removed
  2. waitthe mixture was stirren at room temperature over night
  3. customThe solvent was removed
  4. customthe mixture was purified on HPLC

出典と根拠

ORDレコード
ord-e8f7abd7afdf4d90b628df57a5e0b1e0
出典データセット
uspto-grants-2011_10
特許番号
US08030340B2

反応ノート

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