Sodium Hydroxide → (2-(1,2-Dimethylpropyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol

To a stirred solution of 69.12B (0.050 g, 0.2 mmol) in THF (3 mL) at 0° C. was added LAH (0.3 mL, 0.3 mmol, 1.0M). The reaction was stirred for one hour and then 1N NaOH(aq) was added to the mixture. The reaction was extracted three times with EtOAc. After drying over anhydrous magnesium sulfate and filtering, the organic solvent was removed under reduced pressure and the product was purified on silica gel (0-20% EtOAc in hexanes) to yield 69.12C as a colorless oil (0.011 g, 24% yield).

1. extractionThe reaction was extracted three times with EtOAc
2. dry with materialAfter drying over anhydrous magnesium sulfate
3. filtrationfiltering
4. customthe organic solvent was removed under reduced pressure
5. customthe product was purified on silica gel (0-20% EtOAc in hexanes)

ORDレコード

ord-8debc30864a34e129fd9d376f983a2c3

出典データセット

uspto-grants-2011_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08030354B2