5-Amino-2-chlorobenzoic acid → 2-Chloro-5-(Cyclohexanecarboxamido)Benzoic Acid

HRID 1662833

反応式

HRID 1662833 の反応式
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[CH:12]1([C:18](Cl)=[O:19])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>C1COCC1>[Cl:11][C:5]1[CH:4]=[CH:3][C:2]([NH:1][C:18]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[O:19])=[CH:10][C:6]=1[C:7]([OH:9])=[O:8]

参加物

4

反応物 2

HCID 378795-Amino-2-chlorobenzoic acidHCID 75938Cyclohexanecarbonyl chloride

生成物 1

HCID 549203722-Chloro-5-(Cyclohexanecarboxamido)Benzoic Acid収率 98.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 5-amino-2-chlorobenzoic acid (0.34 g, 2.0 mmol) in THF (10 mL) was charged with cyclohexanecarbonyl chloride (0.27 mL, 1.7 mmol). The reaction was stirred for 16 h and then concentrated in vacuo. The residue was suspended in DCM and filtered to afford the title compounds as a white solid (0.47 g, 97%).

後処理

  1. concentrationconcentrated in vacuo
  2. filtrationfiltered

出典と根拠

ORDレコード
ord-c95b7900514f4738a107f2e40adbe181
出典データセット
uspto-grants-2011_10
特許番号
US08030487B2

関連ノート

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