Thionyl Chloride → 2-Chloro-N-{2-[4-(4-Methyl-Piperazine-1-Carbonyl)-Phenylamino]-Pyrimidin-5-yl}-5-(3-Trifluoromethyl-Benzoylamino)-Benzamide

反応式

[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]([CH:19]=[CH:20][CH:21]=1)[C:6]([NH:8][C:9]1[CH:10]=[CH:11][C:12]([Cl:18])=[C:13]([CH:17]=1)[C:14](O)=[O:15])=[O:7].S(Cl)(Cl)=O.[NH2:28][C:29]1[CH:30]=[N:31][C:32]([NH:35][C:36]2[CH:41]=[CH:40][C:39]([C:42]([N:44]3[CH2:49][CH2:48][N:47]([CH3:50])[CH2:46][CH2:45]3)=[O:43])=[CH:38][CH:37]=2)=[N:33][CH:34]=1>ClCCl.C1COCC1>[Cl:18][C:12]1[CH:11]=[CH:10][C:9]([NH:8][C:6](=[O:7])[C:5]2[CH:19]=[CH:20][CH:21]=[C:3]([C:2]([F:1])([F:22])[F:23])[CH:4]=2)=[CH:17][C:13]=1[C:14]([NH:28][C:29]1[CH:34]=[N:33][C:32]([NH:35][C:36]2[CH:41]=[CH:40][C:39]([C:42]([N:44]3[CH2:49][CH2:48][N:47]([CH3:50])[CH2:46][CH2:45]3)=[O:43])=[CH:38][CH:37]=2)=[N:31][CH:30]=1)=[O:15]